History of mental and neurological disorders in first-to-fourth degree family members is associated with an increased risk for autism spectrum disorder (ASD), according to study results published in JAMA Network Open.
The study cohort included 567,436 index persons, 51.3% of whom were male. The mean age of all participants at the end of follow-up was 14.3 years. The prevalence of ASD with intellectual disability (ASD-ID; n=2566) and without ID (ASD-No ID; n=8354) was 0.4% and 1.5%, respectively.